Solid-state nanopores have gained much attention as a bioanalytical platform. By virtue of their tunable nanoscale dimensions, nanopore sensors can a spatial resolution that spans a wide range of biological species from a single-molecule to a single virus or microorganism. Several groups have already used solid-state nanopores for tag-free detection of viruses. However, no one has reported use of nanopores to capture a single virus for further interrogation by the electric field inside nanopores. In this paper we will report detection of single HIV-1 particle with solid-state nanopores and demonstrate the ability to trap a single HIV-1 particle on top of a nanopore and force it to squeeze through the pore using an electric field.

Date Published: 13 May 2015
PDF: 7 pages
Proc. SPIE 9490, Advances in Global Health through Sensing Technologies 2015, 94900M (13 May 2015); doi: 10.1117/12.2183320

Published in SPIE Proceedings Vol. 9490:
Advances in Global Health through Sensing Technologies 2015
Šárka O. Southern; Mark A. Mentzer; Virginia E. Wotring, Editor(s)