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Proceedings Paper

Identification of atherosclerosis using aminolevulinic gold nanoparticle assay in fecal specimens
Author(s): Karina de O. Gonçalves; Mônica N. da Silva; Lilia C. Courrol
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Paper Abstract

The atheromatous plaques exhibit an accumulation of protoporphyrin IX, or PpIX, which is transferred to the feces. In this work it was associated a precursor of the PpIX, the 5-aminolevulinic acid, ALA, with gold nanoparticles (ALA:AuNps). The objective was verify the possibility to use ALA:AuNPs as a diagnosis agent for atherosclerosis. ALA:AuNps were synthesized mixing ALA with Tetrachloroauric(III) acid in miliQ water solution followed by photoreduction with light from a Xenon lamp. A total of 22 Male New Zealand rabbits were divided into 3 groups: control group (CG) where animals received normal diet, control group with ALA (CGALA ) and Experimental Group with ALA:AuNPs ( EGALAAu ) in which the animals received a diet with 1% cholesterol. Measurements of the emission intensity of extracted porphyrins from the feces in the region between 575 and 725 nm were done. An increase in the feces porphyrin emission after ALA and ALA:AuNPs administration was observed.

Paper Details

Date Published: 19 June 2015
PDF: 6 pages
Proc. SPIE 9531, Biophotonics South America, 953142 (19 June 2015); doi: 10.1117/12.2180916
Show Author Affiliations
Karina de O. Gonçalves, Univ. Federal de São Paulo (Brazil)
Mônica N. da Silva, Univ. Federal de São Paulo (Brazil)
Lilia C. Courrol, Univ. Federal de São Paulo (Brazil)

Published in SPIE Proceedings Vol. 9531:
Biophotonics South America
Cristina Kurachi D.D.S.; Katarina Svanberg M.D.; Bruce J. Tromberg; Vanderlei Salvador Bagnato, Editor(s)

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