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Proceedings Paper

Innovative parameters obtained for digital analysis of microscopic images to evaluate in vitro hemorheological action of anesthetics
Author(s): Analía I. Alet; Sabrina Basso; Marcela Delannoy; Nicolás A. Alet; Mabel D'Arrigo; Horacio V. Castellini; Bibiana D. Riquelme
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Paper Abstract

Drugs used during anesthesia could enhance microvascular flow disturbance, not only for their systemic cardiovascular actions but also by a direct effect on the microcirculation and in particular on hemorheology. This is particularly important in high-risk surgical patients such as those with vascular disease (diabetes, hypertension, etc.). Therefore, in this work we propose a set of innovative parameters obtained by digital analysis of microscopic images to study the in vitro hemorheological effect of propofol and vecuronium on red blood cell from type 2 diabetic patients compared to healthy donors. Obtained innovative parameters allow quantifying alterations in erythrocyte aggregation, which can increase the in vivo risk of microcapillary obstruction.

Paper Details

Date Published: 19 June 2015
PDF: 6 pages
Proc. SPIE 9531, Biophotonics South America, 95311P (19 June 2015); doi: 10.1117/12.2180791
Show Author Affiliations
Analía I. Alet, Univ. Nacional de Rosario (Argentina)
Sabrina Basso, Univ. Nacional de Rosario (Argentina)
Marcela Delannoy, Univ. Nacional de Rosario (Argentina)
Nicolás A. Alet, Univ. Nacional de Rosario (Argentina)
Hospital de Emergencias Clemente Álvarez (Argentina)
Mabel D'Arrigo, Univ. Nacional de Rosario (Argentina)
CONICET-UNR (Argentina)
Horacio V. Castellini, Univ. Nacional de Rosario (Argentina)
Bibiana D. Riquelme, Univ. Nacional de Rosario (Argentina)
CONICET-UNR (Argentina)

Published in SPIE Proceedings Vol. 9531:
Biophotonics South America
Cristina Kurachi D.D.S.; Katarina Svanberg M.D.; Bruce J. Tromberg; Vanderlei Salvador Bagnato, Editor(s)

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