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Proceedings Paper

3D Monte Carlo radiation transfer modelling of photodynamic therapy
Author(s): C. Louise Campbell; Craig Christison; C. Tom A. Brown; Kenneth Wood; Ronan M. Valentine; Harry Moseley
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Paper Abstract

The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.

Paper Details

Date Published: 19 June 2015
PDF: 13 pages
Proc. SPIE 9531, Biophotonics South America, 95311H (19 June 2015); doi: 10.1117/12.2180744
Show Author Affiliations
C. Louise Campbell, Univ. of St. Andrews (United Kingdom)
Craig Christison, Univ. of St. Andrews (United Kingdom)
C. Tom A. Brown, Univ. of St. Andrews (United Kingdom)
Kenneth Wood, Univ. of St. Andrews (United Kingdom)
Ronan M. Valentine, Ninewells Hospital and Medical School, Univ. of Dundee (United Kingdom)
Harry Moseley, Ninewells Hospital and Medical School, Univ. of Dundee (United Kingdom)

Published in SPIE Proceedings Vol. 9531:
Biophotonics South America
Cristina Kurachi D.D.S.; Katarina Svanberg M.D.; Bruce J. Tromberg; Vanderlei Salvador Bagnato, Editor(s)

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