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Proceedings Paper

Applications of Raman spectroscopy in life science
Author(s): Airton A. Martin; Cláudio A. T. Soto; Syed M. Ali; Lázaro P. M. Neto; Renata A. Canevari; Liliane Pereira; Priscila P. Fávero
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Paper Abstract

Raman spectroscopy has been applied to the analysis of biological samples for the last 12 years providing detection of changes occurring at the molecular level during the pathological transformation of the tissue. The potential use of this technology in cancer diagnosis has shown encouraging results for the in vivo, real-time and minimally invasive diagnosis. Confocal Raman technics has also been successfully applied in the analysis of skin aging process providing new insights in this field. In this paper it is presented the latest biomedical applications of Raman spectroscopy in our laboratory. It is shown that Raman spectroscopy (RS) has been used for biochemical and molecular characterization of thyroid tissue by micro-Raman spectroscopy and gene expression analysis. This study aimed to improve the discrimination between different thyroid pathologies by Raman analysis. A total of 35 thyroid tissues samples including normal tissue (n=10), goiter (n=10), papillary (n=10) and follicular carcinomas (n=5) were analyzed. The confocal Raman spectroscopy allowed a maximum discrimination of 91.1% between normal and tumor tissues, 84.8% between benign and malignant pathologies and 84.6% among carcinomas analyzed. It will be also report the application of in vivo confocal Raman spectroscopy as an important sensor for detecting advanced glycation products (AGEs) on human skin.

Paper Details

Date Published: 19 June 2015
PDF: 7 pages
Proc. SPIE 9531, Biophotonics South America, 95311L (19 June 2015); doi: 10.1117/12.2180653
Show Author Affiliations
Airton A. Martin, Univ. do Paraíba (Brazil)
Cláudio A. T. Soto, Univ. do Paraíba (Brazil)
Syed M. Ali, Univ. do Paraíba (Brazil)
Lázaro P. M. Neto, Univ. do Paraíba (Brazil)
Renata A. Canevari, Univ. do Paraíba (Brazil)
Liliane Pereira, Univ. do Paraíba (Brazil)
Priscila P. Fávero, Univ. do Paraíba (Brazil)

Published in SPIE Proceedings Vol. 9531:
Biophotonics South America
Cristina Kurachi D.D.S.; Katarina Svanberg M.D.; Bruce J. Tromberg; Vanderlei Salvador Bagnato, Editor(s)

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