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Proceedings Paper

Hydrodynamic stretching for prostate cancer detection
Author(s): Yuri Belotti; Michael Conneely; Scott Palmer; Tianjun Huang; Paul Campbell; Stephen McKenna; Ghulam Nabi; David McGloin
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Paper Abstract

Advances in diagnostic technologies enabled scientists to link a large number of diseases with structural changes of the intracellular organisation. This intrinsic biophysical characteristic opened up the possibility to perform clinical assessments based on the measurement of single-cell mechanical properties. In this work, we combine microfluidics, high speed imaging and computational automatic tracking to measure the single-cell deformability of large samples of prostate cancer cells at a rate of ~ 104cells/s. Such a high throughput accounts for the inherent heterogeneity of biological samples and enabled us to extract statistically meaningful signatures from each cell population. In addition, using our technique we investigate the effect of Latrunculin A to the cellular stiffness.

Paper Details

Date Published: 1 June 2015
PDF: 8 pages
Proc. SPIE 9518, Bio-MEMS and Medical Microdevices II, 95180H (1 June 2015); doi: 10.1117/12.2179201
Show Author Affiliations
Yuri Belotti, Univ. of Dundee (United Kingdom)
Michael Conneely, Univ. of Dundee (United Kingdom)
Scott Palmer, Univ. of Dundee (United Kingdom)
Tianjun Huang, Univ. of Dundee (United Kingdom)
Paul Campbell, Univ. of Dundee (United Kingdom)
Stephen McKenna, Univ. of Dundee (United Kingdom)
Ghulam Nabi, Univ. of Dundee (United Kingdom)
David McGloin, Univ. of Dundee (United Kingdom)

Published in SPIE Proceedings Vol. 9518:
Bio-MEMS and Medical Microdevices II
Sander van den Driesche, Editor(s)

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