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Proceedings Paper

Characterization of new drug delivery nanosystems using atomic force microscopy
Author(s): Ellas Spyratou; Elena A. Mourelatou; C. Demetzos; Mersini Makropoulou; A. A. Serafetinides
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Paper Abstract

Liposomes are the most attractive lipid vesicles for targeted drug delivery in nanomedicine, behaving also as cell models in biophotonics research. The characterization of the micro-mechanical properties of drug carriers is an important issue and many analytical techniques are employed, as, for example, optical tweezers and atomic force microscopy. In this work, polyol hyperbranched polymers (HBPs) have been employed along with liposomes for the preparation of new chimeric advanced drug delivery nanosystems (Chi-aDDnSs). Aliphatic polyester HBPs with three different pseudogenerations G2, G3 and G4 with 16, 32, and 64 peripheral hydroxyl groups, respectively, have been incorporated in liposomal formulation. The atomic force microscopy (AFM) technique was used for the comparative study of the morphology and the mechanical properties of Chi-aDDnSs and conventional DDnS. The effects of both the HBPs architecture and the polyesters pseudogeneration number in the stability and the stiffness of chi-aDDnSs were examined. From the force-distance curves of AFM spectroscopy, the Young’s modulus was calculated.

Paper Details

Date Published: 8 January 2015
PDF: 9 pages
Proc. SPIE 9447, 18th International School on Quantum Electronics: Laser Physics and Applications, 944714 (8 January 2015); doi: 10.1117/12.2178483
Show Author Affiliations
Ellas Spyratou, National Technical Univ. of Athens (Greece)
Elena A. Mourelatou, National and Kapodistrian Univ. of Athens (Greece)
C. Demetzos, National and Kapodistrian Univ. of Athens (Greece)
Mersini Makropoulou, National Technical Univ. of Athens (Greece)
A. A. Serafetinides, National Technical Univ. of Athens (Greece)

Published in SPIE Proceedings Vol. 9447:
18th International School on Quantum Electronics: Laser Physics and Applications
Tanja Dreischuh; Sanka Gateva; Alexandros Serafetinides, Editor(s)

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