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Proceedings Paper

Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system
Author(s): Nathan McDannold; Yongzhi Zhang; Chanikarn Power; Costas D. Arvanitis; Natalia Vykhodtseva; Margaret Livingstone
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Paper Abstract

The physiology of the vasculature in the central nervous system (CNS), which includes the blood-brain barrier (BBB) and other factors, complicates the delivery of most drugs to the brain. Different methods have been used to bypass the BBB, but they have limitations such as being invasive, non-targeted or requiring the formulation of new drugs. Focused ultrasound (FUS), when combined with circulating microbubbles, is a noninvasive method to locally and transiently disrupt the BBB at discrete targets. The method presents new opportunities for the use of drugs and for the study of the brain.

Paper Details

Date Published: 22 May 2015
PDF: 4 pages
Proc. SPIE 9467, Micro- and Nanotechnology Sensors, Systems, and Applications VII, 94670H (22 May 2015); doi: 10.1117/12.2178134
Show Author Affiliations
Nathan McDannold, Harvard Medical School (United States)
Yongzhi Zhang, Harvard Medical School (United States)
Chanikarn Power, Harvard Medical School (United States)
Costas D. Arvanitis, Harvard Medical School (United States)
Natalia Vykhodtseva, Harvard Medical School (United States)
Margaret Livingstone, Harvard Medical School (United States)

Published in SPIE Proceedings Vol. 9467:
Micro- and Nanotechnology Sensors, Systems, and Applications VII
Thomas George; Achyut K. Dutta; M. Saif Islam, Editor(s)

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