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Proceedings Paper

Dynamic analysis and performance evaluation of the BIAcore surface plasmon resonance biosensor
Author(s): Laurent Simon; Juan Ospina
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Paper Abstract

Solution procedures were proposed to analyze nonlinear mass transport through an optical biosensor. A generalized collocation technique was applied to predict the dynamic behavior of an analyte along the flow chamber as a result of convection, diffusion and chemical reaction. The method estimated the effective time constants for reaching average steady-state concentrations of the free and bound analytes in the cell. When diffusion in the direction of flow was neglected, a closed-form solution, based on double Laplace transforms, was obtained after linearizing the original system. In both models, an increase in the sample diffusion coefficient lowered the effective time constant. This approach may help researchers evaluate the performance of biosensors and meet specific design criteria.

Paper Details

Date Published: 13 May 2015
PDF: 11 pages
Proc. SPIE 9487, Smart Biomedical and Physiological Sensor Technology XII, 94870E (13 May 2015); doi: 10.1117/12.2177807
Show Author Affiliations
Laurent Simon, New Jersey Institute of Technology (United States)
Juan Ospina, Univ. EAFIT (Colombia)

Published in SPIE Proceedings Vol. 9487:
Smart Biomedical and Physiological Sensor Technology XII
Brian M. Cullum; Eric S. McLamore, Editor(s)

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