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Proceedings Paper

3D noninvasive, high-resolution imaging using a photoacoustic tomography (PAT) system and rapid wavelength-cycling lasers
Author(s): Ashwin Sampathkumar; Daniel Gross; Marc Klosner; Gary Chan; Chunbai Wu; Donald F. Heller
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Paper Abstract

Globally, cancer is a major health issue as advances in modern medicine continue to extend the human life span. Breast cancer ranks second as a cause of cancer death in women in the United States. Photoacoustic (PA) imaging (PAI) provides high molecular contrast at greater depths in tissue without the use of ionizing radiation. In this work, we describe the development of a PA tomography (PAT) system and a rapid wavelength-cycling Alexandrite laser designed for clinical PAI applications. The laser produces 450 mJ/pulse at 25 Hz to illuminate the entire breast, which eliminates the need to scan the laser source. Wavelength cycling provides a pulse sequence in which the output wavelength repeatedly alternates between 755 nm and 797 nm rapidly within milliseconds. We present imaging results of breast phantoms with inclusions of different sizes at varying depths, obtained with this laser source, a 5-MHz 128-element transducer and a 128-channel Verasonics system. Results include PA images and 3D reconstruction of the breast phantom at 755 and 797 nm, delineating the inclusions that mimic tumors in the breast.

Paper Details

Date Published: 13 May 2015
PDF: 7 pages
Proc. SPIE 9487, Smart Biomedical and Physiological Sensor Technology XII, 94870I (13 May 2015); doi: 10.1117/12.2177602
Show Author Affiliations
Ashwin Sampathkumar, Riverside Research Institute (United States)
Daniel Gross, Riverside Research Institute (United States)
Marc Klosner, Light Age, Inc. (United States)
Gary Chan, Light Age, Inc. (United States)
Chunbai Wu, Light Age, Inc. (United States)
Donald F. Heller, Light Age, Inc. (United States)

Published in SPIE Proceedings Vol. 9487:
Smart Biomedical and Physiological Sensor Technology XII
Brian M. Cullum; Eric S. McLamore, Editor(s)

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