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Proceedings Paper

Total least squares (TLS) regression, wavelength, and chromophore selection analysis in NIRS data quantification
Author(s): Sabine Van Huffel; Paul Casaer; Peter Van Mele; Gert Willems
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Paper Abstract

An accuracy analysis is made of currently used near infrared spectroscopy (NIRS) algorithms, based on the Beer-Lambert law, for quantification of chromophore concentration changes in neonatal brain. In particular, the regression method and chromophores considered, as well as the influence of the wavelength-dependent extinction coefficients, on the accuracy of the computed concetration changes of Hb, HbO2, and Cytaa3 is investigated. The total least squares method, which considers errors in the specific extinction coefficients as well, is able to double the accuracy (compared to least squares), when appropriate weights, derived from the error variances, are added and enough wavelength measurements (> 100) are available. Furthermore, the influence of the number of wavelenghts used, as well as the importance of the choice of the wavelength sebset, is studied. It is shown that the accuracy significantly increases, up to 10 wavelengths. Additionally, optimizing the condition number of the extinction coefficient matrix allows to select small wavelength subsets that clearly outperform presently used sets in accuracy for all computed concentration changes. Finally, the influence of the chromphores, such as H2O is shown. H2O may only be included in the model when enough wavelengths (> 100) are used for NIRS measurement or when the chosen subset minimizes the condition number of the corresponding extinction coefficient matrix.

Paper Details

Date Published: 30 May 1995
PDF: 12 pages
Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, (30 May 1995); doi: 10.1117/12.210032
Show Author Affiliations
Sabine Van Huffel, Katholieke Univ. Leuven (Belgium)
Paul Casaer, Univ. Hospital Gasthuisberg (Belgium)
Peter Van Mele, Katholieke Univ. Leuven (Belgium)
Gert Willems, Katholieke Univ. Leuven (Belgium)


Published in SPIE Proceedings Vol. 2389:
Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
Britton Chance; Robert R. Alfano, Editor(s)

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