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Proceedings Paper

Discriminating the size and density of objects within tissue: frequency-domain versus steady-state measurements
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Paper Abstract

Steady-state (SS) optical measurements are simpler and less expensive than frequency-domain (FD) measurements. So why bother with FD? This paper illustrates the advantage obtained by FD vs. SS, using computer simulated experiments. A single shperical object is placed in the center of our model for the human prostate. The object is given a range of sized and values for its incremental absorption ((Delta) (mu) a) above the background medium (bloodless prostate), with the condition that the optical volume (equals object volume X (Delta) (mu) a) remains constant. Simulations of SS measurements and FD measurements using a 3 GHz modulation frequency were conducted and two measurements simulated: the frequency difference ((Delta) P equals phase with object--phase without object) and the relative amplitude (A/A0 equals amplitude with object/amplitude without object). The results show that A/A0 at SS and 3 GHz are very similar in their response to the object size, and the (Delta) P at 3 GHz offered important additional information.

Paper Details

Date Published: 30 May 1995
PDF: 12 pages
Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, (30 May 1995); doi: 10.1117/12.209971
Show Author Affiliations
Steven L. Jacques, Univ. of Texas M.D. Anderson Cancer Ctr. and Rice Univ. (United States)
Andreas H. Hielscher, Univ. of Texas M.D. Anderson Cancer Ctr. and Rice Univ. (United States)


Published in SPIE Proceedings Vol. 2389:
Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
Britton Chance; Robert R. Alfano, Editor(s)

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