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Proceedings Paper

Estimation of regional pulmonary perfusion parameters from microfocal angiograms
Author(s): Anne V. Clough; Amir Al-Tinawi; John H. Linehan; Christopher A. Dawson
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Paper Abstract

An important application of functional imaging is the estimation of regional blood flow and volume using residue detection of vascular indicators. An indicator-dilution model applicable to tissue regions distal from the inlet site was developed. Theoretical methods for determining regional blood flow, volume, and mean transit time parameters from time-absorbance curves arise from this model. The robustness of the parameter estimation methods was evaluated using a computer-simulated vessel network model. Flow through arterioles, networks of capillaries, and venules was simulated. Parameter identification and practical implementation issues were addressed. The shape of the inlet concentration curve and moderate amounts of random noise did not effect the ability of the method to recover accurate parameter estimates. The parameter estimates degraded in the presence of significant dispersion of the measured inlet concentration curve as it traveled through arteries upstream from the microvascular region. The methods were applied to image data obtained using microfocal x-ray angiography to study the pulmonary microcirculation. Time- absorbance curves were acquired from a small feeding artery, the surrounding microvasculature and a draining vein of an isolated dog lung as contrast material passed through the field-of-view. Changes in regional microvascular volume were determined from these curves.

Paper Details

Date Published: 24 May 1995
PDF: 13 pages
Proc. SPIE 2433, Medical Imaging 1995: Physiology and Function from Multidimensional Images, (24 May 1995); doi: 10.1117/12.209679
Show Author Affiliations
Anne V. Clough, Marquette Univ. (United States)
Amir Al-Tinawi, Marquette Univ. (United States)
John H. Linehan, Marquette Univ. (United States)
Christopher A. Dawson, Zablocki Veterans Administration Medical Ctr. (United States)
Medical College of Wisconsin (United States)

Published in SPIE Proceedings Vol. 2433:
Medical Imaging 1995: Physiology and Function from Multidimensional Images
Eric A. Hoffman, Editor(s)

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