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Proceedings Paper

Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research
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Paper Abstract

In this work, we introduce an improved prototype of the imaging system that combines three-dimensional optoacoustic tomography (3D-OAT) and laser ultrasound tomography slicer (2D-LUT) to obtain coregistered maps of tissue optical absorption and speed of sound (SOS). The imaging scan is performed by a 360 degree rotation of a phantom/mouse with respect to a static arc-shaped array of ultrasonic transducers. A Q-switched laser system is used to establish optoacoustic illumination pattern appropriate for deep tissue imaging with a tunable (730-840 nm) output wavelengths operated at 10 Hz pulse repetition rate. For the LUT slicer scans, the array is pivoted by 90 degrees with respect to the central transducers providing accurate registration of optoacoustic and SOS maps, the latter being reconstructed using waveform inversion with source encoding (WISE) technique. The coregistered OAT-LUT modality is validated by imaging a phantom and a live mouse. SOS maps acquired in the imaging system can be employed by an iterative optoacoustic reconstruction algorithm capable of compensating for acoustic wavefield aberrations. The most promising applications of the imaging system include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents (carbon nanotubes, metal plasmonic nanoparticles, fluorophores, etc.).

Paper Details

Date Published: 11 March 2015
PDF: 8 pages
Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93230N (11 March 2015); doi: 10.1117/12.2085028
Show Author Affiliations
Sergey A. Ermilov, TomoWave Laboratories, Inc. (United States)
Richard Su, TomoWave Laboratories, Inc. (United States)
Univ. of Houston (United States)
Andre Conjusteau, TomoWave Laboratories, Inc. (United States)
Tanmayi Oruganti, TomoWave Laboratories, Inc. (United States)
Kun Wang, Washington Univ. in St. Louis (United States)
Fatima Anis, Washington Univ. in St. Louis (United States)
Mark A. Anastasio, Washington Univ. in St. Louis (United States)
Alexander A. Oraevsky, TomoWave Laboratories, Inc. (United States)
Univ. of Houston (United States)

Published in SPIE Proceedings Vol. 9323:
Photons Plus Ultrasound: Imaging and Sensing 2015
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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