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Proceedings Paper

Towards intraoperative surgical margin assessment and visualization using bioimpedance properties of the tissue
Author(s): Shadab Khan; Aditya Mahara; Elias S. Hyams; Alan Schned; Ryan Halter
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Paper Abstract

Prostate cancer (PCa) has a high 10-year recurrence rate, making PCa the second leading cause of cancer-specific mortality among men in the USA. PCa recurrences are often predicted by assessing the status of surgical margins (SM) with positive surgical margins (PSM) increasing the chances of biochemical recurrence by 2-4 times. To this end, an SM assessment system using Electrical Impedance Spectroscopy (EIS) was developed with a microendoscopic probe. This system measures the tissue bioimpedance over a range of frequencies (1 kHz to 1MHz), and computes a Composite Impedance Metric (CIM). CIM can be used to classify tissue as benign or cancerous. The system was used to collect the impedance spectra from excised prostates, which were obtained from men undergoing radical prostatectomy. The data revealed statistically significant (p<0.05) differences in the impedance properties of the benign and tumorous tissues, and between different tissue morphologies. To visualize the results of SM-assessment, a visualization tool using da Vinci stereo laparoscope is being developed. Together with the visualization tool, the EIS-based SM assessment system can be potentially used to intraoperatively classify tissues and display the results on the surgical console with a video feed of the surgical site, thereby augmenting a surgeon’s view of the site and providing a potential solution to the intraoperative SM assessment needs.

Paper Details

Date Published: 20 March 2015
PDF: 6 pages
Proc. SPIE 9414, Medical Imaging 2015: Computer-Aided Diagnosis, 94141C (20 March 2015); doi: 10.1117/12.2082920
Show Author Affiliations
Shadab Khan, Dartmouth College (United States)
Aditya Mahara, Dartmouth College (United States)
Elias S. Hyams, Dartmouth-Hitchcock Medical Ctr. (United States)
Alan Schned, Dartmouth-Hitchcock Medical Ctr. (United States)
Ryan Halter, Dartmouth College (United States)

Published in SPIE Proceedings Vol. 9414:
Medical Imaging 2015: Computer-Aided Diagnosis
Lubomir M. Hadjiiski; Georgia D. Tourassi, Editor(s)

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