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Proceedings Paper

Combined concurrent nanoshell loaded macrophage-mediated photothermal and photodynamic therapies
Author(s): Henry Hirschberg M.D.; Anthony Trinidad; Catherine E. Christie M.D.; Qian Peng M.D.; Young J. Kwon; Steen Madsen III
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Paper Abstract

Macrophages loaded with gold nanoshells (AuNS), that convert near infrared light to heat, can be used as transport vectors for photothermal hyperthermia of tumors. The purpose of this study was to investigate the effects of combined macrophage mediated photothermal therapy (PTT) and PDT on head and neck squamous cell carcinoma (HNSCC). The results provide proof of concept for the use of macrophages as a delivery vector of AuNS for photothermal enhancement of the effects of PDT on squamous cell carcinoma. A significant synergy was demonstrated with combined PDT and PTT compared to each modality applied separately.

Paper Details

Date Published: 26 February 2015
PDF: 5 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 930322 (26 February 2015); doi: 10.1117/12.2082850
Show Author Affiliations
Henry Hirschberg M.D., Beckman Laser Institute and Medical Clinic (United States)
Univ. of Nevada, Las Vegas (United States)
Anthony Trinidad, Beckman Laser Institute and Medical Clinic (United States)
Catherine E. Christie M.D., Beckman Laser Institute and Medical Clinic (United States)
Qian Peng M.D., Oslo Univ. Hospital (Norway)
Young J. Kwon, Univ. of California, Irvine (United States)
Steen Madsen III, Univ. of Nevada, Las Vegas (United States)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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