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Proceedings Paper

Simultaneous measurement of cerebral and muscle tissue parameters during cardiac arrest and cardiopulmonary resuscitation
Author(s): Reyhaneh Nosrati; Andrew Ramadeen; Xudong Hu; Ermias Woldemichael; Siwook Kim; Paul Dorian; Vladislav Toronov
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Paper Abstract

In this series of animal experiments on resuscitation after cardiac arrest we had a unique opportunity to measure hyperspectral near-infrared spectroscopy (hNIRS) parameters directly on the brain dura, or on the brain through the intact pig skull, and simultaneously the muscle hNIRS parameters. Simultaneously the arterial blood pressure and carotid and femoral blood flow were recorded in real time using invasive sensors. We used a novel hyperspectral signalprocessing algorithm to extract time-dependent concentrations of water, hemoglobin, and redox state of cytochrome c oxidase during cardiac arrest and resuscitation. In addition in order to assess the validity of the non-invasive brain measurements the obtained results from the open brain was compared to the results acquired through the skull. The comparison of hNIRS data acquired on brain surface and through the adult pig skull shows that in both cases the hemoglobin and the redox state cytochrome c oxidase changed in similar ways in similar situations and in agreement with blood pressure and flow changes. The comparison of simultaneously measured brain and muscle changes showed expected differences. Overall the results show feasibility of transcranial hNIRS measurements cerebral parameters including the redox state of cytochrome oxidase in human cardiac arrest patients.

Paper Details

Date Published: 10 March 2015
PDF: 6 pages
Proc. SPIE 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II, 93051G (10 March 2015); doi: 10.1117/12.2082819
Show Author Affiliations
Reyhaneh Nosrati, Ryerson Univ (Canada)
Andrew Ramadeen, St. Michael's Hospital (Canada)
Xudong Hu, St. Michael's Hospital (Canada)
Ermias Woldemichael, Ryerson Univ. (Canada)
Siwook Kim, Ryerson Univ. (Canada)
Paul Dorian, St. Michael's Hospital (Canada)
Centenial College (Canada)
Vladislav Toronov, Ryerson Univ. (Canada)

Published in SPIE Proceedings Vol. 9305:
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II
Henry Hirschberg M.D.; E. Duco Jansen; Samarendra K. Mohanty; Nitish V. Thakor; Qingming Luo; Steen J. Madsen, Editor(s)

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