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Proceedings Paper

In vivo imaging of microvascular changes in inflammatory human skin induced by tape stripping and mosquito saliva using optical microangiography
Author(s): Utku Baran; Woo J. Choi; Ruikang K. Wang
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Paper Abstract

Tape stripping on human skin induces mechanical disruptions of the epidermal barrier that lead to minor skin inflammation which leads to temporary changes in microvasculature. On the other hand, when mosquitoes probe the skin for blood feeding, they inject saliva in dermal tissue. Mosquito saliva is known to exert various biological activities, such as dermal mast cell degranulation, leading to fluid extravasation and neutrophil influx. This inflammatory response remain longer than the tape stripping caused inflammation. In this study, we demonstrate the capabilities of swept-source optical coherence tomography (OCT) in detecting in vivo microvascular response of inflammatory human skin. Optical microangiography (OMAG), noninvasive volumetric microvasculature in vivo imaging method, has been used to track the vascular responses after tape stripping and mosquito bite. Vessel density has been quantified and used to correlate with the degree of skin irritation. The proved capability of OMAG technique in visualizing the microvasculature network under inflamed skin condition can play an important role in clinical trials of treatment and diagnosis of inflammatory skin disorders as well as studying mosquito bite’s perception by the immune system and its role in parasite transmission.

Paper Details

Date Published: 5 March 2015
PDF: 4 pages
Proc. SPIE 9322, Dynamics and Fluctuations in Biomedical Photonics XII, 93220N (5 March 2015); doi: 10.1117/12.2082722
Show Author Affiliations
Utku Baran, Univ. of Washington (United States)
Woo J. Choi, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)

Published in SPIE Proceedings Vol. 9322:
Dynamics and Fluctuations in Biomedical Photonics XII
Valery V. Tuchin; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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