Optofluidic schemes of inhibition, transport and activation by carrier molecules through cell membrane have interesting applications. Through plasmonic excitation of nanoparticles integrated in microfluidic channel, we observe cell membrane structural changes. Related phenomena are studied in situ in a microfluidic channel via fluorescence imaging. Detailed analysis is carried out to understand the possible application of this scheme in optically induced transport and expression of cell membrane protein. Optical properties of the cells undergoing plasmonic transport are monitored and correlated to cell expression assay. Plasmonic charge transport and optical transmission are measured in the microfluidic lab-on-chip along with in-situ imaging.

Date Published: 2 March 2015
PDF: 6 pages
Proc. SPIE 9310, Frontiers in Biological Detection: From Nanosensors to Systems VII, 93100A (2 March 2015); doi: 10.1117/12.2082598

Published in SPIE Proceedings Vol. 9310:
Frontiers in Biological Detection: From Nanosensors to Systems VII
Benjamin L. Miller; Philippe M. Fauchet; Brian T. Cunningham, Editor(s)