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Proceedings Paper

The study of photoacoustic imaging without nanoparticles as a contrast agent for anti-body drug monitoring
Author(s): Seung Hee Han; Jeeun Kang; Brian Wilson; Tai-Kyong Song; Young Il Kim
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Paper Abstract

As an emerging hybrid Imaging, Photoacoustic became a powerful tool that can scan disease at the deeper site in tissue and monitor of drug delivery in vivo. PAI system used nano-particle as contrast agent to enhance the PA signal in deeper site in tissue. So this makes that PAI’s application have some limitation for monitoring of all kinds of anti-body drug, because of various anti-body’s absorption excitation. In this study, we designed a PAI system with a tunable pulse OPO laser (from 450~700nm excitation wavelength) to show the optimal wavelength for monitoring of the antibody drug; doxorubicin having peak absorption at near 500nm excitation without any nano-particle combine. We made a gelatin phantoms having 4 different concentration doxorubicin as an anti-body drug; Doxorubicin concentration were in- 0mg/ml, 0.5mg/ml, 1mg/ml, and 2mg/ml. We found that 500nm is optimization wavelength to produce PA peak signal and PAI can be tool to monitor of anti-body drug without contrast agent.

Paper Details

Date Published: 17 March 2015
PDF: 5 pages
Proc. SPIE 9419, Medical Imaging 2015: Ultrasonic Imaging and Tomography, 94190B (17 March 2015); doi: 10.1117/12.2082439
Show Author Affiliations
Seung Hee Han, Sogang Univ. (Korea, Republic of)
Ontario Cancer Institute (Canada)
Sogang Univ. (Korea, Republic of)
Jeeun Kang, Sogang Univ. (Korea, Republic of)
Brian Wilson, Ontario Cancer Institute (Canada)
Univ. of Toronto (Canada)
Tai-Kyong Song, Sogang Univ. (Korea, Republic of)
Young Il Kim, Seoul National Univ. College of Medicine (Korea, Republic of)

Published in SPIE Proceedings Vol. 9419:
Medical Imaging 2015: Ultrasonic Imaging and Tomography
Johan G. Bosch; Neb Duric, Editor(s)

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