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Proceedings Paper

Ultrasensitive quantification of cerebral capillary flow networks and dynamics
Author(s): Jiang You; Ki Park; Congwu Du; Yingtian Pan
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Paper Abstract

Ultra-high resolution optical Doppler coherence tomography (μODT) is a promising tool for brain functional imaging. However, its sensitivity for detecting slow flows in capillary beds may limit its utility in visualizing and quantifying subtle changes in brain microcirculation. To address this limitation, we developed a novel method called contrast-enhanced μODT (c-μODT) in which intralipid is injected into mouse tail vein to enhance μODT detection sensitivity. We demonstrate that after intralipid injection, the flow detection sensitivity of μODT is dramatically enhanced by 230% as quantified by the fill factor (FF) of microvasculature. More importantly, we show that c-μODT preserves the quantitative properties for flow imaging, i.e., showing a comparable change ratio of hypercapnia-induced flow increase in the capillary network before and after injecting intralipid.

Paper Details

Date Published: 2 March 2015
PDF: 5 pages
Proc. SPIE 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX, 931218 (2 March 2015); doi: 10.1117/12.2082428
Show Author Affiliations
Jiang You, Stony Brook Univ. (United States)
Ki Park, Stony Brook Univ. (United States)
Congwu Du, Stony Brook Univ. (United States)
Yingtian Pan, Stony Brook Univ. (United States)


Published in SPIE Proceedings Vol. 9312:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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