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Proceedings Paper

Subcortical shape and volume abnormalities in an elderly HIV+ cohort
Author(s): Benjamin S. C. Wade; Victor Valcour; Edgar Busovaca; Pardis Esmaeili-Firidouni; Shantanu H. Joshi; Yalin Wang; Paul M. Thompson
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Paper Abstract

Over 50% of HIV+ individuals show significant impairment in psychomotor functioning, processing speed, working memory and attention [1, 2]. Patients receiving combination antiretroviral therapy may still have subcortical atrophy, but the profile of HIV-associated brain changes is poorly understood. With parametric surface-based shape analyses, we mapped the 3D profile of subcortical morphometry in 63 elderly HIV+ subjects (4 female; age=65.35 ± 2.21) and 31 uninfected elderly controls (2 female; age=64.68 ± 4.57) scanned with MRI as part of a San Francisco Bay Area study of elderly people with HIV. We also investigated whether morphometry was associated with nadir CD4+ (T-cell) counts, viral load and illness duration among HIV+ participants. FreeSurfer was used to segment the thalamus, caudate, putamen, pallidum, hippocampus, amygdala, accumbens, brainstem, callosum and ventricles from brain MRI scans. To study subcortical shape, we analyzed: (1) the Jacobian determinant (JD) indexed over structures’ surface coordinates and (2) radial distances (RD) of structure surfaces from a medial curve. A JD less than 1 reflects regional tissue atrophy and greater than 1 reflects expansion. The volumes of several subcortical regions were found to be associated with HIV status. No regional volumes showed detectable associations with CD4 counts, viral load or illness duration. The shapes of numerous subcortical regions were significantly linked to HIV status, detectability of viral RNA and illness duration. Our results show subcortical brain differences in HIV+ subjects in both shape and volumetric domains.

Paper Details

Date Published: 17 March 2015
PDF: 8 pages
Proc. SPIE 9417, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, 94171S (17 March 2015); doi: 10.1117/12.2082241
Show Author Affiliations
Benjamin S. C. Wade, The Univ. of Southern California (United States)
Victor Valcour, Univ. of California, San Francisco (United States)
Edgar Busovaca, Columbia Univ. Medical Ctr. (United States)
Pardis Esmaeili-Firidouni, Columbia Univ. Medical Ctr. (United States)
Shantanu H. Joshi, Univ. of California, Los Angeles (United States)
Yalin Wang, Arizona State Univ. (United States)
Paul M. Thompson, Univ. of California, Los Angeles (United States)

Published in SPIE Proceedings Vol. 9417:
Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Robert C. Molthen, Editor(s)

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