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Proceedings Paper

Comparing consistency of R2* and T2*-weighted BOLD analysis of resting state fetal fMRI
Author(s): Sharmishtaa Seshamani; Anna I. Blazejewska; Christopher Gatenby; Susan Mckown; Jason Caucutt; Manjiri Dighe; Colin Studholme
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Paper Abstract

Understanding when and how resting state brain functional activity begins in the human brain is an increasing area of interest in both basic neuroscience and in the clinical evaluation of the brain during pregnancy and after premature birth. Although fMRI studies have been carried out on pregnant women since the 1990's, reliable mapping of brain function in utero is an extremely challenging problem due to the unconstrained fetal head motion. Recent studies have employed scrubbing to exclude parts of the time series and whole subjects from studies in order to control the confounds of motion. Fundamentally, even after correction of the location of signals due to motion, signal intensity variations are a fundamental limitation, due to coil sensitivity and spin history effects. An alternative technique is to use a more parametric MRI signal derived from multiple echoes that provides a level of independence from basic MRI signal variation. Here we examine the use of R2* mapping combined with slice based multi echo geometric distortion correction for in-utero studies. The challenges for R2* mapping arise from the relatively low signal strength of in-utero data. In this paper we focus on comparing activation detection in-utero using T2W and R2* approaches. We make use a subset of studies with relatively limited motion to compare the activation patterns without the additional confound of significant motion. Results at different gestational ages indicate comparable agreement in many activation patterns when limited motion is present, and the detection of some additional networks in the R2* data, not seen in the T2W results.

Paper Details

Date Published: 19 March 2015
PDF: 10 pages
Proc. SPIE 9417, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, 94170N (19 March 2015); doi: 10.1117/12.2082236
Show Author Affiliations
Sharmishtaa Seshamani, Univ. of Washington (United States)
Anna I. Blazejewska, Univ. of Washington (United States)
Christopher Gatenby, Univ. of Washington (United States)
Susan Mckown, Univ. of Washington (United States)
Jason Caucutt, Univ. of Washington (United States)
Manjiri Dighe, Univ. of Washington (United States)
Colin Studholme, Univ. of Washington (United States)

Published in SPIE Proceedings Vol. 9417:
Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Robert C. Molthen, Editor(s)

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