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Proceedings Paper

Analysis of the Vancouver lung nodule malignancy model with respect to manual and automated segmentation
Author(s): Rafael Wiemker; Lilla Boroczky; Martin Bergtholdt; Tobias Klinder
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Paper Abstract

The recently published Vancouver model for lung nodule malignancy prediction holds great promise as a practically feasible tool to mitigate the clinical decision problem of how to act on a lung nodule detected at baseline screening. It provides a formula to compute a probability of malignancy from only nine clinical and radiologic features. The feature values are provided by user interaction but in principle could also be automatically pre-filled by appropriate image processing algorithms and RIS requests. Nodule diameter is a feature with crucial influence on the predicted malignancy, and leads to uncertainty caused by inter-reader variability. The purpose of this paper is to analyze how strongly the malignancy prediction of a lung nodule found with CT screening is affected by the inter-reader variation of the nodule diameter estimation. To this aim we have estimated the magnitude of the malignancy variability by applying the Vancouver malignancy model to the LIDC-IDRI database which contains independent delineations from several readers. It can be shown that using fully automatic nodule segmentation can significantly lower the variability of the estimated malignancy, while demonstrating excellent agreement with the expert readers.

Paper Details

Date Published: 20 March 2015
PDF: 8 pages
Proc. SPIE 9414, Medical Imaging 2015: Computer-Aided Diagnosis, 94140B (20 March 2015); doi: 10.1117/12.2081917
Show Author Affiliations
Rafael Wiemker, Philips Research (Germany)
Lilla Boroczky, Philips Research North America (United States)
Martin Bergtholdt, Philips Research (Germany)
Tobias Klinder, Philips Research (Germany)

Published in SPIE Proceedings Vol. 9414:
Medical Imaging 2015: Computer-Aided Diagnosis
Lubomir M. Hadjiiski; Georgia D. Tourassi, Editor(s)

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