There is currently an increasing interest in combining the information obtained from radiology and histology with the intent of gaining a better understanding of how different tumour morphologies can lead to distinctive radiological signs which might predict overall treatment outcome. Relating information at different resolution scales is challenging. Reconstructing 3D volumes from histology images could be the key to interpreting and relating the radiological image signal to tissue microstructure. The goal of this study is to determine the minimum sampling (maximum spacing between histological sections through a fixed surgical specimen) required to create a 3D reconstruction of the specimen to a specific tolerance. We present initial results for one lumpectomy specimen case where 33 consecutive histology slides were acquired.

Date Published: 19 March 2015
PDF: 13 pages
Proc. SPIE 9420, Medical Imaging 2015: Digital Pathology, 94200K (19 March 2015); doi: 10.1117/12.2081909

Published in SPIE Proceedings Vol. 9420:
Medical Imaging 2015: Digital Pathology
Metin N. Gurcan; Anant Madabhushi, Editor(s)