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Proceedings Paper

Detection of squamous carcinoma cells using gold nanoparticles
Author(s): Wei-Yun Dai; Sze-tsen Lee; Yih-Chih Hsu
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Paper Abstract

The goal of this study is to use gold nanoparticle as a diagnostic agent to detect human squamous carcinoma cells. Gold nanoparticles were synthesized and the gold nanoparticle size was 34.3 ± 6.2 nm. Based on the over-expression of epidermal growth factor receptor (EGFR) biomarkers in squamous carcinoma cells, we hypothesized that EGFR could be a feasible biomarker with a target moiety for detection. We further modified polyclonal antibodies of EGFR on the surface of gold nanoparticles. We found selected squamous carcinoma cells can be selectively detected using EGFR antibody-modified gold nanoparticles via receptor-mediated endocytosis. Cell death was also examined to determine the survival status of squamous carcinoma cells with respect to gold nanoparticle treatment and EGFR polyclonal antibody modification.

Paper Details

Date Published: 9 March 2015
PDF: 5 pages
Proc. SPIE 9324, Biophotonics and Immune Responses X, 93240N (9 March 2015); doi: 10.1117/12.2081783
Show Author Affiliations
Wei-Yun Dai, Chung Yuan Christian Univ. (Taiwan)
Sze-tsen Lee, Chung Yuan Christian Univ. (Taiwan)
Yih-Chih Hsu, Chung Yuan Christian Univ. (Taiwan)

Published in SPIE Proceedings Vol. 9324:
Biophotonics and Immune Responses X
Wei R. Chen, Editor(s)

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