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Proceedings Paper

Heritability analysis of surface-based cortical thickness estimation on a large twin cohort
Author(s): Kaikai Shen; Vincent Doré; Stephen Rose; Jurgen Fripp; Katie L. McMahon; Greig I. de Zubicaray; Nicholas G. Martin; Paul M. Thompson; Margaret J. Wright; Olivier Salvado
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Paper Abstract

The aim of this paper is to assess the heritability of cerebral cortex, based on measurements of grey matter (GM) thickness derived from structural MR images (sMRI). With data acquired from a large twin cohort (328 subjects), an automated method was used to estimate the cortical thickness, and EM-ICP surface registration algorithm was used to establish the correspondence of cortex across the population. An ACE model was then employed to compute the heritability of cortical thickness. Heritable cortical thickness measures various cortical regions, especially in frontal and parietal lobes, such as bilateral postcentral gyri, superior occipital gyri, superior parietal gyri, precuneus, the orbital part of the right frontal gyrus, right medial superior frontal gyrus, right middle occipital gyrus, right paracentral lobule, left precentral gyrus, and left dorsolateral superior frontal gyrus.

Paper Details

Date Published: 20 March 2015
PDF: 8 pages
Proc. SPIE 9413, Medical Imaging 2015: Image Processing, 94131Z (20 March 2015); doi: 10.1117/12.2081677
Show Author Affiliations
Kaikai Shen, CSIRO Digital Productivity Flagship (Australia)
Vincent Doré, CSIRO Digital Productivity Flagship (Australia)
Stephen Rose, CSIRO Digital Productivity Flagship (Australia)
Jurgen Fripp, CSIRO Digital Productivity Flagship (Australia)
Katie L. McMahon, The Univ. of Queensland (Australia)
Greig I. de Zubicaray, The Univ. of Queensland (Australia)
Nicholas G. Martin, Queensland Institute of Medical Research (Australia)
Paul M. Thompson, The Univ. of Southern California (United States)
Margaret J. Wright, Queensland Institute of Medical Research (Australia)
Olivier Salvado, CSIRO Digital Productivity Flagship (Australia)

Published in SPIE Proceedings Vol. 9413:
Medical Imaging 2015: Image Processing
Sébastien Ourselin; Martin A. Styner, Editor(s)

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