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Proceedings Paper

Quantification, validation, and follow-up of small bowel motility in Crohn's disease
Author(s): Juan J. Cerrolaza; Jennifer Q. Peng; Nabile M. Safdar M.D.; Laurie Conklin; Raymond Sze; Marius George Linguraru
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Paper Abstract

The use of magnetic resonance enterography (MRE) has become a mainstay in the evaluation, assessment and follow up of inflammatory bowel diseases, such as Crohn’s disease (CD), thanks to its high image quality and its non-ionizing nature. In particular, the advent of faster MRE sequences less sensitive to image-motion artifacts offers the possibility to obtain visual, structural and functional information of the patient’s small bowel. However, the inherent subjectivity of the mere visual inspection of these images often hinders the accurate identification and monitoring of the pathological areas. In this paper, we present a framework that provides quantitative and objective motility information of the small bowel from free-breathing MRE dynamic sequences. After compensating for the breathing motion of the patient, we create personalized peristaltic activity maps via optical flow analysis. The result is the creation of a new set of images providing objective and precise functional information of the small bowel. The accuracy of the new method was also evaluated from two different perspectives: objective accuracy (1.1 ± 0.6 mm/s of error), i.e., the ability of the system to provide quantitative and accurate information about the motility of moving bowel landmarks, and subjective accuracy (avg. difference of 0.7 ± 0.7 in a range of 1 to 5), i.e., the degree of agreement with the subjective evaluation of an expert. Finally, the practical utility of the new method was successfully evaluated in a preliminary study with 32 studies of healthy and CD cases, showing its potential for the fast and accurate assessment and follow up of CD in the small bowel.

Paper Details

Date Published: 20 March 2015
PDF: 6 pages
Proc. SPIE 9414, Medical Imaging 2015: Computer-Aided Diagnosis, 94141D (20 March 2015); doi: 10.1117/12.2081480
Show Author Affiliations
Juan J. Cerrolaza, Children's National Health System (United States)
Jennifer Q. Peng, Children's National Health System (United States)
Princeton Univ. (United States)
Nabile M. Safdar M.D., Children's National Health System (United States)
Laurie Conklin, Children’s National Health System (United States)
Raymond Sze, Children's National Health System (United States)
Marius George Linguraru, Children's National Health System (United States)
George Washington Univ. (United States)

Published in SPIE Proceedings Vol. 9414:
Medical Imaging 2015: Computer-Aided Diagnosis
Lubomir M. Hadjiiski; Georgia D. Tourassi, Editor(s)

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