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Proceedings Paper

3D MR ventricle segmentation in pre-term infants with post-hemorrhagic ventricle dilation
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Paper Abstract

Intraventricular hemorrhage (IVH) or bleed within the brain is a common condition among pre-term infants that occurs in very low birth weight preterm neonates. The prognosis is further worsened by the development of progressive ventricular dilatation, i.e., post-hemorrhagic ventricle dilation (PHVD), which occurs in 10-30% of IVH patients. In practice, predicting PHVD accurately and determining if that specific patient with ventricular dilatation requires the ability to measure accurately ventricular volume. While monitoring of PHVD in infants is typically done by repeated US and not MRI, once the patient has been treated, the follow-up over the lifetime of the patient is done by MRI. While manual segmentation is still seen as a gold standard, it is extremely time consuming, and therefore not feasible in a clinical context, and it also has a large inter- and intra-observer variability. This paper proposes a segmentation algorithm to extract the cerebral ventricles from 3D T1- weighted MR images of pre-term infants with PHVD. The proposed segmentation algorithm makes use of the convex optimization technique combined with the learned priors of image intensities and label probabilistic map, which is built from a multi-atlas registration scheme. The leave-one-out cross validation using 7 PHVD patient T1 weighted MR images showed that the proposed method yielded a mean DSC of 89.7% ± 4.2%, a MAD of 2.6 ± 1.1 mm, a MAXD of 17.8 ± 6.2 mm, and a VD of 11.6% ± 5.9%, suggesting a good agreement with manual segmentations.

Paper Details

Date Published: 20 March 2015
PDF: 6 pages
Proc. SPIE 9413, Medical Imaging 2015: Image Processing, 941310 (20 March 2015); doi: 10.1117/12.2081467
Show Author Affiliations
Wu Qiu, Univ. of Western Ontario (Canada)
Jing Yuan, Univ. of Western Ontario (Canada)
Jessica Kishimoto, Univ. of Western Ontario (Canada)
Yimin Chen, City Univ. of Hong Kong (China)
Sandrine de Ribaupierre, Univ. of Western Ontario (Canada)
Bernard Chiu, City Univ. of Hong Kong (China)
Aaron Fenster, Univ. of Western Ontario (Canada)

Published in SPIE Proceedings Vol. 9413:
Medical Imaging 2015: Image Processing
Sébastien Ourselin; Martin A. Styner, Editor(s)

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