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Proceedings Paper

Getting the most out of additional guidance information in deformable image registration by leveraging multi-objective optimization
Author(s): Tanja Alderliesten; Peter A. N. Bosman; Arjan Bel
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Paper Abstract

Incorporating additional guidance information, e.g., landmark/contour correspondence, in deformable image registration is often desirable and is typically done by adding constraints or cost terms to the optimization function. Commonly, deciding between a “hard” constraint and a “soft” additional cost term as well as the weighting of cost terms in the optimization function is done on a trial-and-error basis. The aim of this study is to investigate the advantages of exploiting guidance information by taking a multi-objective optimization perspective. Hereto, next to objectives related to match quality and amount of deformation, we define a third objective related to guidance information. Multi-objective optimization eliminates the need to a-priori tune a weighting of objectives in a single optimization function or the strict requirement of fulfilling hard guidance constraints. Instead, Pareto-efficient trade-offs between all objectives are found, effectively making the introduction of guidance information straightforward, independent of its type or scale. Further, since complete Pareto fronts also contain less interesting parts (i.e., solutions with near-zero deformation effort), we study how adaptive steering mechanisms can be incorporated to automatically focus more on solutions of interest. We performed experiments on artificial and real clinical data with large differences, including disappearing structures. Results show the substantial benefit of using additional guidance information. Moreover, compared to the 2-objective case, additional computational cost is negligible. Finally, with the same computational budget, use of the adaptive steering mechanism provides superior solutions in the area of interest.

Paper Details

Date Published: 20 March 2015
PDF: 7 pages
Proc. SPIE 9413, Medical Imaging 2015: Image Processing, 94131R (20 March 2015); doi: 10.1117/12.2081438
Show Author Affiliations
Tanja Alderliesten, Academisch Medisch Centrum (Netherlands)
Peter A. N. Bosman, Ctr. voor Wiskunde en Informatica (Netherlands)
Arjan Bel, Academisch Medisch Centrum (Netherlands)

Published in SPIE Proceedings Vol. 9413:
Medical Imaging 2015: Image Processing
Sébastien Ourselin; Martin A. Styner, Editor(s)

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