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Proceedings Paper

Preferential alignment of birefringent tissue measured with polarization sensitive techniques
Author(s): J. C. Ramella-Roman; T. Ruiz; P. Ghassemi; T. E. Travis; J. W. Shupp; J. Chue-Sang; Y. Bai
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Paper Abstract

Assessing collagen alignment is of interest when evaluating a therapeutic strategy and evaluating its outcome in scar management. In this work we introduce a theoretical and experimental methodology for the quantification of collagen and birefringent media alignment based on polarized light transport. The technique relies on the fact that these materials exhibit directional anisotropy. A polarized Monte Carlo model and a spectro-polarimetric imaging system were devised to predict and measure the impact of birefringence on an impinging polarized light beam. Experiments conducted on birefringent phantoms, and biological samples consisting of highly packed parallel birefringent fibers, showed a good agreement with the analytical results.

Paper Details

Date Published: 26 February 2015
PDF: 5 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93030I (26 February 2015); doi: 10.1117/12.2081338
Show Author Affiliations
J. C. Ramella-Roman, Florida International Univ. (United States)
T. Ruiz, Florida International Univ. (United States)
P. Ghassemi, The Catholic Univ. of America (United States)
T. E. Travis, MedStar Washington Hospital Ctr. (United States)
J. W. Shupp, MedStar Washington Hospital Ctr. (United States)
J. Chue-Sang, Florida International Univ. (United States)
Y. Bai, Florida International Univ. (United States)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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