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Proceedings Paper

Vascular wall stress during intravascular optical coherence tomography imaging
Author(s): Cuiru Sun; Victor Yang
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Paper Abstract

Biomechanical properties of arterial wall is crucial for understanding the changes in the cardiovascular system. Catheters are used during intravascular optical coherence tomography (IVOCT) imaging. The presence of a catheter alters the flow field, pressure distribution and frictional resistance to flow in an artery. In this paper, we first study the transmural stress distribution of the catheterized vessel. COMSOL (COMSOL 4.4) was used to simulate the blood flow induced deformation in a catheterized vessel. Blood is modeled as an incompressible Newtonian fluid. Stress distribution from an three-layer vascular model with an eccentric catheter are simulated, which provides a general idea about the distribution of the displacement and the stress. Optical coherence elastography techniques were then applied to porcine carotid artery samples to look at the deformation status of the vascular wall during saline or water injection. Preliminary simulation results show nonuniform stress distribution in the circumferential direction of the eccentrically catheterized vascular model. Three strain rate methods were tested for intravascular OCE application. The tissue Doppler method has the potential to be further developed to image the vascular wall biomechnical properties in vivo. Although results in this study are not validated quantitatively, the experiments and methods may be valuable for intravascular OCE studies, which may provide important information for cardiovascular disease prevention, diagnosis and treatment.

Paper Details

Date Published: 19 March 2015
PDF: 5 pages
Proc. SPIE 9327, Optical Elastography and Tissue Biomechanics II, 93270E (19 March 2015); doi: 10.1117/12.2080649
Show Author Affiliations
Cuiru Sun, Ryerson Univ. (Canada)
Tianjin Univ. (China)
Victor Yang, Ryerson Univ. (Canada)
Sunnybrook Health Sciences Ctr. (Canada)
Univ. of Toronto (Canada)

Published in SPIE Proceedings Vol. 9327:
Optical Elastography and Tissue Biomechanics II
Kirill V. Larin; David D. Sampson, Editor(s)

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