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Proceedings Paper

Paper-basd surface enhanced Raman spectroscopy of pnenobarbital sodium for point-of-care therapeutic drug monitoring
Author(s): Moe Yokoyama; Kenji Yamada; Takahiro Nishimura; Michiko Kido; Hieyong Jeong; Yuko Ohno
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Paper Abstract

Therapeutic drug monitoring (TDM) contributes to safe and effective pharmacotherapy in clinical fields. A simple, rapid, low-cost, and minimally-invasive drug measurement method attracts much interest for point-of-care TDM. Tear fluids can be collected minimally-invasively compared to blood sampling and there is a correlation between a drug concentration in tears and that in bloods. Surface enhanced Raman spectroscopy (SERS) with paper-based substrate is useful for point-of-care TDM owing to inexpensiveness and high-sensitivity. Paper is also a safe tear collection tool. Then we are studying on a paper-based SERS of tear specimen for point-of-care TDM. In this paper, to improve sensitivity in measuring drug concentration in tear fluids, we fabricated a SERS substrate by coating gold nano-rods on a paper substrate and evaluated whether the fabricated substrate can enhance Raman scattering. Sodium phenobarbital (PB), an anti-convulsant agent, was used as a target. In experiment, the fabricated substrate indicated the lower detection limit of PB in a solution than a plain paper substrate. This result showed the potential of the paper based SERS substrate to measure drug concentration in tears simply and inexpensively.

Paper Details

Date Published: 10 April 2015
PDF: 4 pages
Proc. SPIE 9332, Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics, 933210 (10 April 2015); doi: 10.1117/12.2080619
Show Author Affiliations
Moe Yokoyama, Osaka Univ. (Japan)
Kenji Yamada, Osaka Univ. (Japan)
Takahiro Nishimura, Osaka Univ. (Japan)
Michiko Kido, Osaka Univ. (Japan)
Hieyong Jeong, Osaka Univ. (Japan)
Yuko Ohno, Osaka Univ. (Japan)

Published in SPIE Proceedings Vol. 9332:
Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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