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Proceedings Paper

Microvascular complications associated with injection of cosmetic facelift dermal fillers
Author(s): Siavash Yousefi; Mark Prendes M.D.; Shu-Hong Chang M.D.; Ruikang K. Wang
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Paper Abstract

Minimally-invasive cosmetic surgeries such as injection of subdermal fillers have become very popular in the past decade. Although rare, some complications may follow injections such as tissue necrosis and even blindness. There exist two hypothesis regarding source of these complications both of which include microvasculature. The first hypothesis is that fillers in between the tissue structures and compress microvasculature that causes blockage of tissue neutrition and oxygen exchange in the tissue. In another theory, it is hypothesized that fillers move inside major arteries and block the arteries/veins. In this paper, we study these hypotheses using optical coherence tomography and optical microangiography technologies with different hyaluronic-acid fillers in a mouse ear model. Based on our observations, the fillers eventually block arteries/veins if injected directly into them that eventually causes tissue necrosis.

Paper Details

Date Published: 26 February 2015
PDF: 10 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93030D (26 February 2015); doi: 10.1117/12.2080534
Show Author Affiliations
Siavash Yousefi, Stanford Univ. (United States)
Univ. of Washington (United States)
Mark Prendes M.D., Univ. of Washington (United States)
Shu-Hong Chang M.D., Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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