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Proceedings Paper

Silica-coated gold nanostars for surface-enhanced resonance Raman spectroscopy mapping of integrins in breast cancer cells
Author(s): Michael B. Fenn Jr.; Nikša Roki; Chris Bashur
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Paper Abstract

Surface-Enhanced Resonance Raman Spectroscopy (SERRS) has great potential for improving cancer research and diagnosis. Capable of sub-femtomolar detection, and a high degree of multiplexing, SERRS is an attractive new technique for studying cancer biology. We have developed PEGylated silica-coated gold nanostars that can be tuned to match the Raman laser-light source wavelength, providing high-level SERRS/SERS enhancement when combined with various reporter molecules. Furthermore, the particles were conjugated with cyclo-RGDf/k peptide to investigate integrin expression of breast cancer cells using high-speed Raman mapping. We propose that this may provide a better understanding of the role of integrins in breast cancer invasiveness.

Paper Details

Date Published: 20 March 2015
PDF: 12 pages
Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 934006 (20 March 2015); doi: 10.1117/12.2080443
Show Author Affiliations
Michael B. Fenn Jr., Florida Institute of Technology (United States)
Nikša Roki, Florida Institute of Technology (United States)
Chris Bashur, Florida Institute of Technology (United States)

Published in SPIE Proceedings Vol. 9340:
Plasmonics in Biology and Medicine XII
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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