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Proceedings Paper

Efficacy of combined photothermal therapy and chemotherapeutic drugs
Author(s): Steen J. Madsen; En-Chung Shih; Henry Hirschberg M.D.
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Paper Abstract

Hyperthermia has been shown to enhance the effects of chemotherapeutic agents in a wide variety of cancers. The purpose of this study was to investigate the combined effects of a number of commonly used chemotherapeutic drugs (bleomycin, doxorubicin and cisplatin) with photothermal therapy (PTT)-induced hyperthermia in an in vitro system consisting of human head and neck squamous carcinoma cells and murine lymphocytic monocytes which were used as delivery vehicles for gold-silica nanoshells (AuNS). PTT was accomplished via near infra-red (NIR) irradiation of AuNS. The results showed that PTT combined with cisplatin resulted in only a mild degree of synergism while additive effects were observed for concurrent treatments of PTT and doxorubicin and PTT and bleomycin.

Paper Details

Date Published: 10 March 2015
PDF: 8 pages
Proc. SPIE 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II, 93050E (10 March 2015); doi: 10.1117/12.2080354
Show Author Affiliations
Steen J. Madsen, Univ. of Nevada, Las Vegas (United States)
En-Chung Shih, Univ. of Nevada, Las Vegas (United States)
Henry Hirschberg M.D., Beckman Laser Institute and Medical Clinic (United States)

Published in SPIE Proceedings Vol. 9305:
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II
Henry Hirschberg M.D.; E. Duco Jansen; Samarendra K. Mohanty; Nitish V. Thakor; Qingming Luo; Steen J. Madsen, Editor(s)

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