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Proceedings Paper

Reinforcement of osteogenesis with nanofabricated hydroxyapatite and GelMA nanocomposite
Author(s): Zhaokai Meng; Chandani Chitrakar; Akhilesh K. Gaharwar; Vladislav V. Yakovlev
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Paper Abstract

Every year in the United States approximately 1.5 million people are suffering from bone fractures. Current treatment solutions include surgeries and grafting process; however, it does not show any osteoconductive action, which is an essential character for biomaterials. The main objective of the reported studies is to develop a novel nanocomposite comprising of hydroxyapatite nanospheres (~40nm) and gelatin methacrylate to promote bone regeneration without any osteoinductive factors. To validate our hypothesis that chemical and mechanical properties of nanocomposite get enhanced, we employed various characterization techniques including Brillouin and Raman spectroscopies. The results imply that hydroxyaoatite nanoparticles are capable of enhancing the macroscopic stiffness at the structural level. To the contrary, Brillouin spectroscopy suggests that the microscopic elasticity of the nanocomposite was weakened.

Paper Details

Date Published: 6 April 2015
PDF: 7 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 930340 (6 April 2015); doi: 10.1117/12.2080301
Show Author Affiliations
Zhaokai Meng, Texas A&M Univ. (United States)
Chandani Chitrakar, Texas A&M Univ. (United States)
Akhilesh K. Gaharwar, Texas A&M Univ. (United States)
Vladislav V. Yakovlev, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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