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Proceedings Paper

Ex-vivo glucose sensors using micro-dialysis: importance of on-line recovery rate determination by multi-analyte infrared spectrometry
Author(s): Thorsten Vahlsing; Sven Delbeck; Janpeter Budde; Lars Cocchieri; Dieter Ihrig; Steffen Leonhardt; H. Michael Heise
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Paper Abstract

Micro-dialysis has been established in the clinical environment for continuously harvesting body fluids, but a drawback of this process are variable recovery rates, which can be observed especially for subcutaneously implanted catheters. Perfusates with either acetate or mannitol have been investigated as recovery markers. The latter substance is suggested for application with external cavity tuneable quantum cascade lasers, rendering a limited wavenumber interval in contrast to FTIR-spectrometers. Despite the overlap of mannitol and glucose spectra, their simultaneous quantification was successful. By investigating the depletion of the marker substances from the perfusates using different micro-dialysis devices, the theoretical nonlinear relationship between the relative dialysate marker concentration and glucose recovery rate was confirmed for the marker substance-analyte pair of acetate and glucose, rendering a basis for reliable blood glucose measurements. For the pair of mannitol and glucose an almost linear dependency was expected for the microdialysate catheters and experimentally verified, which provides a straightforward correction of any dialysis recovery rate variation during patient monitoring.

Paper Details

Date Published: 9 March 2015
PDF: 12 pages
Proc. SPIE 9332, Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics, 933209 (9 March 2015); doi: 10.1117/12.2080289
Show Author Affiliations
Thorsten Vahlsing, Fachhochschule Südwestfalen (Germany)
RWTH Aachen Univ. (Germany)
Sven Delbeck, Fachhochschule Südwestfalen (Germany)
Janpeter Budde, Fachhochschule Südwestfalen (Germany)
Lars Cocchieri, Fachhochschule Südwestfalen (Germany)
Dieter Ihrig, Fachhochschule Südwestfalen (Germany)
Steffen Leonhardt, RWTH Aachen Univ. (Germany)
H. Michael Heise, Fachhochschule Südwestfalen (Germany)

Published in SPIE Proceedings Vol. 9332:
Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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