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Proceedings Paper

Photoacoustic imaging: a potential new platform for assessment of bone health
Author(s): Ting Feng; Kenneth M. Kozloff; Yi-Sing Hsiao; Guan Xu; Sidan Du; Jie Yuan; Cheri X. Deng; Xueding Wang
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Paper Abstract

The ultimate goal of this work is to develop a novel photoacoustic (QPA) platform for highly-sensitive and quantitative assessment of bone health. First, the feasibility to perform 3D photoacoustic imaging (PAI) of bone was investigated. Then another two techniques, including thermal photoacoustic measurement (TPAM) and photoacoustic spectral analysis (PASA), both being able to achieve quantitative results were investigated for bone characterization. TPAM, by evaluating the dependence of photoacoustic signal amplitude on the sample temperature, is sensitive to the chemical constituents in tissue and holds promise for assessment of bone mineral density (BMD). PASA characterizes micron size physical features in tissue, and has shown feasibility for objective assessment of bone microarchitecture (BMA). This integrated QPA platform can assess both bone mass and microstructure simultaneously without involving invasive biopsy or ionizing radiation. Since QPA is non-ionizing, non-invasive, and has sufficient penetration in both soft tissue and bone, it has unique advantages for clinical translation.

Paper Details

Date Published: 26 February 2015
PDF: 9 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93033W (26 February 2015); doi: 10.1117/12.2080095
Show Author Affiliations
Ting Feng, Univ. of Michigan, Ann Arbor (United States)
Nanjing Univ. (China)
Kenneth M. Kozloff, Univ. of Michigan, Ann Arbor (United States)
Yi-Sing Hsiao, Univ. of Michigan, Ann Arbor (United States)
Guan Xu, Univ. of Michigan, Ann Arbor (United States)
Sidan Du, Nanjing Univ. (China)
Jie Yuan, Nanjing Univ. (China)
Cheri X. Deng, Univ. of Michigan, Ann Arbor (United States)
Xueding Wang, Univ. of Michigan, Ann Arbor (United States)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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