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Proceedings Paper • Open Access

QPI for prostate cancer diagnosis: quantitative separation of Gleason grades 3 and 4
Author(s): Shamira Sridharan; Virgilia Macias; Krishnarao Tangella; Andre Kajdacsy-Balla; Gabriel Popescu

Paper Abstract

1 in 7 men receive a diagnosis of prostate cancer in their lifetime. The aggressiveness of the treatment plan adopted by the patient is strongly influenced by Gleason grade. Gleason grade is determined by the pathologist based on the level of glandular formation and complexity seen in the patient’s biopsy. However, studies have shown that the disagreement rate between pathologists on Gleason grades 3 and 4 is high and this affects treatment options. We used quantitative phase imaging to develop an objective method for Gleason grading. Using the glandular solidity, which is the ratio of the area of the gland to a convex hull fit around it, and anisotropy of light scattered from the stroma immediately adjoining the gland, we were able to quantitatively separate Gleason grades 3 and 4 with 81% accuracy in 43 cases marked as difficult by pathologists.

Paper Details

Date Published: 11 March 2015
PDF: 6 pages
Proc. SPIE 9336, Quantitative Phase Imaging, 93361U (11 March 2015); doi: 10.1117/12.2080067
Show Author Affiliations
Shamira Sridharan, Univ. of Illinois at Urbana-Champaign (United States)
Virgilia Macias, Univ. of Illinois at Chicago (United States)
Krishnarao Tangella, Univ. of Illinois at Urbana-Champaign (United States)
Andre Kajdacsy-Balla, Univ. of Illinois at Chicago (United States)
Gabriel Popescu, Univ. of Illinois at Urbana-Champaign (United States)

Published in SPIE Proceedings Vol. 9336:
Quantitative Phase Imaging
Gabriel Popescu; YongKeun Park, Editor(s)

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