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Proceedings Paper

Quantitative assessment of hyaline cartilage elasticity during optical clearing using optical coherence elastography
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Paper Abstract

We report the first study on using optical coherence elastography (OCE) to quantitatively monitor the elasticity change of the hyaline cartilage during the optical clearing administrated by glucose solution. The measurement of the elasticity is verified using uniaxial compression test, demonstrating the feasibility of using OCE to quantify the Young’s modulus of the cartilage tissue. As the results, we found that the stiffness of the hyaline cartilage increases during the optical clearing of the tissue. This study might be potentially useful for the early detection of osteoarthritis disease.

Paper Details

Date Published: 5 March 2015
PDF: 9 pages
Proc. SPIE 9322, Dynamics and Fluctuations in Biomedical Photonics XII, 93220B (5 March 2015); doi: 10.1117/12.2079854
Show Author Affiliations
Chih-Hao Liu, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Jiasong Li, Univ. of Houston (United States)
Zhaolong Han, Univ. of Houston (United States)
Chen Wu, Univ. of Houston (United States)
Shang Wang, Baylor College of Medicine (United States)
Rita Idugboe, Univ. of Houston (United States)
Raksha Raghunathan, Univ. of Houston (United States)
Valery P. Zakharov, Samara State Aerospace Univ. (Russian Federation)
Emil N. Sobol, Moscow State Univ. (Russian Federation)
Valery V. Tuchin, Samara State Aerospace Univ. (Russian Federation)
Saratov State Univ. (Russian Federation)
Tomsk State Univ. (Russian Federation)
Michael Twa, Univ. of Houston (United States)
Kirill V. Larin, Univ. of Houston (United States)
Samara State Aerospace Univ. (Russian Federation)
Saratov State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 9322:
Dynamics and Fluctuations in Biomedical Photonics XII
Valery V. Tuchin; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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