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Proceedings Paper

Development of new devices for detection of gastric cancer on laparoscopic surgery using near-infrared light
Author(s): Shunko A. Inada; Shingo Fuchi; Kensaku Mori; Junichi Hasegawa; Kazunari Misawa M.D.; Hayao Nakanishi
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Paper Abstract

In recent year, for the treatment of gastric cancer the laparoscopic surgery is performed, which has good benefits, such as low-burden, low-invasive and the efficacy is equivalent to the open surgery. For identify location of the tumor intraperitoneally for extirpation of the gastric cancer, several points of charcoal ink is injected around the primary tumor. However, in the time of laparoscopic operation, it is difficult to estimate specific site of primary tumor, because the injected charcoal ink diffusely spread to the area distant from the tumor in the stomach. Therefore, a broad area should be resected which results in a great stress for the patients. To overcome this problem, we focused in the near-infrared wavelength of 1000nm band which have high biological transmission. In this study, we developed a fluorescent clip which was realized with glass phosphor (Yb3+, Nd3+ doped to Bi2O3-B2O3 based glasses. λp: 976 nm, FWHM: 100 nm, size: 2x1x3 mm) and the laparoscopic fluorescent detection system for clip-derived near-infrared light. To evaluate clinical performance of a fluorescent clip and the laparoscopic fluorescent detection system, we used resected stomach (thickness: 13 mm) from the patients. Fluorescent clip was fixed on the gastric mucosa, and an excitation light (λ: 808 nm) was irradiated from outside of stomach for detection of fluorescence through stomach wall. As a result, fluorescence emission from the clip was successfully detected. Furthermore, we confirmed that detection sensitivity of the emission of fluorescence from the clip depends on the output power of the excitation light. We conformed that the fluorescent clip in combination with laparoscopic fluorescent detection system is very useful method to identify the exact location of the primary gastric cancer.

Paper Details

Date Published: 2 March 2015
PDF: 4 pages
Proc. SPIE 9304, Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II, 93041Q (2 March 2015); doi: 10.1117/12.2079814
Show Author Affiliations
Shunko A. Inada, Nagoya Univ. (Japan)
Shingo Fuchi, Aoyama Gakuin Univ. (Japan)
Kensaku Mori, Nagoya Univ. (Japan)
Junichi Hasegawa, Chukyo Univ. (Japan)
Kazunari Misawa M.D., Aichi Cancer Ctr. Hospital (Japan)
Hayao Nakanishi, Aichi Cancer Ctr. Research Institute (Japan)

Published in SPIE Proceedings Vol. 9304:
Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II
Melissa J. Suter; Guillermo J. Tearney M.D.; Thomas D. Wang; Stephen Lam M.D.; Matthew Brenner, Editor(s)

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