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Proceedings Paper

Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography
Author(s): Sripriya Ramamoorthy; Yuan Zhang; Tracy Petrie; Anders Fridberger; Tianying Ren; Ruikang Wang; Steven L. Jacques; Alfred L. Nuttall
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Paper Abstract

In this study, we measure the in vivo apical-turn vibrations of the guinea pig organ of Corti in both axial and radial directions using phase-sensitive Fourier domain optical coherence tomography. The apical turn in guinea pig cochlea has best frequencies around 100 – 500 Hz which are relevant for human speech. Prior measurements of vibrations in the guinea pig apex involved opening the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here this limitation is overcome by measuring the vibrations through bone without opening the otic capsule. Furthermore, we have significantly reduced the surgery needed to access the guinea pig apex in the axial direction by introducing a miniature mirror inside the bulla. The method and preliminary data are discussed in this article.

Paper Details

Date Published: 26 February 2015
PDF: 6 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93031L (26 February 2015); doi: 10.1117/12.2079673
Show Author Affiliations
Sripriya Ramamoorthy, Oregon Health & Science Univ. (United States)
Yuan Zhang, Oregon Health & Science Univ. (United States)
Tracy Petrie, Oregon Health & Science Univ. (United States)
Anders Fridberger, Linköping Univ. (Sweden)
Tianying Ren, Oregon Health & Science Univ. (United States)
Ruikang Wang, Univ. of Washington (United States)
Steven L. Jacques, Oregon Health & Science Univ. (United States)
Alfred L. Nuttall, Oregon Health & Science Univ. (United States)
Univ. of Michigan, Ann Arbor (United States)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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