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Proceedings Paper

Automatic optimization high-speed high-resolution OCT retinal imaging at 1µm
Author(s): Michelle Cua; Xiyun Liu; Dongkai Miao; Sujin Lee; Sieun Lee; Stefano Bonora; Robert J. Zawadzki; Paul J. Mackenzie; Yifan Jian; Marinko V. Sarunic
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Paper Abstract

High-resolution OCT retinal imaging is important in providing visualization of various retinal structures to aid researchers in better understanding the pathogenesis of vision-robbing diseases. However, conventional optical coherence tomography (OCT) systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking optical coherence tomography (OCT) system with automatic optimization for high-resolution, extended-focal-range clinical retinal imaging. A variable-focus liquid lens was added to correct for de-focus in real-time. A GPU-accelerated segmentation and optimization was used to provide real-time layer-specific enface visualization as well as depth-specific focus adjustment. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the ONH, from which we extracted clinically-relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.

Paper Details

Date Published: 20 March 2015
PDF: 7 pages
Proc. SPIE 9307, Ophthalmic Technologies XXV, 93071D (20 March 2015); doi: 10.1117/12.2079665
Show Author Affiliations
Michelle Cua, Simon Fraser Univ. (Canada)
Xiyun Liu, Simon Fraser Univ. (Canada)
Dongkai Miao, Simon Fraser Univ. (Canada)
Sujin Lee, Simon Fraser Univ. (Canada)
Sieun Lee, Simon Fraser Univ. (Canada)
Stefano Bonora, Istituto Nazionale per la Fisica della Materia, CNR (Italy)
Robert J. Zawadzki, Univ. of California, Davis (United States)
Paul J. Mackenzie, The Univ. of British Columbia (Canada)
Yifan Jian, Simon Fraser Univ. (Canada)
Marinko V. Sarunic, Simon Fraser Univ. (Canada)

Published in SPIE Proceedings Vol. 9307:
Ophthalmic Technologies XXV
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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