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Proceedings Paper

Finite element method (FEM) model of the mechanical stress on phospholipid membranes from shock waves produced in nanosecond electric pulses (nsEP)
Author(s): Ronald Barnes; Caleb C. Roth; Mehdi Shadaram; Hope Beier; Bennett L. Ibey
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Paper Abstract

The underlying mechanism(s) responsible for nanoporation of phospholipid membranes by nanosecond pulsed electric fields (nsEP) remains unknown. The passage of a high electric field through a conductive medium creates two primary contributing factors that may induce poration: the electric field interaction at the membrane and the shockwave produced from electrostriction of a polar submersion medium exposed to an electric field. Previous work has focused on the electric field interaction at the cell membrane, through such models as the transport lattice method. Our objective is to model the shock wave cell membrane interaction induced from the density perturbation formed at the rising edge of a high voltage pulse in a polar liquid resulting in a shock wave propagating away from the electrode toward the cell membrane. Utilizing previous data from cell membrane mechanical parameters, and nsEP generated shockwave parameters, an acoustic shock wave model based on the Helmholtz equation for sound pressure was developed and coupled to a cell membrane model with finite-element modeling in COMSOL. The acoustic structure interaction model was developed to illustrate the harmonic membrane displacements and stresses resulting from shockwave and membrane interaction based on Hooke’s law. Poration is predicted by utilizing membrane mechanical breakdown parameters including cortical stress limits and hydrostatic pressure gradients.

Paper Details

Date Published: 12 March 2015
PDF: 5 pages
Proc. SPIE 9326, Energy-based Treatment of Tissue and Assessment VIII, 93260W (12 March 2015); doi: 10.1117/12.2079394
Show Author Affiliations
Ronald Barnes, The Univ. of Texas at San Antonio (United States)
Caleb C. Roth, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Mehdi Shadaram, The Univ. of Texas at San Antonio (United States)
Hope Beier, Air Force Research Lab. (United States)
Bennett L. Ibey, Air Force Research Lab. (United States)

Published in SPIE Proceedings Vol. 9326:
Energy-based Treatment of Tissue and Assessment VIII
Thomas P. Ryan, Editor(s)

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