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Proceedings Paper

Stimulated emission depletion microscopy to study amyloid fibril formation
Author(s): Pierre Mahou; Nathan Curry; Dorothea Pinotsi; Gabriele Kaminski Schierle; Clemens Kaminski
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Paper Abstract

Aggregation of misfolded proteins is a characteristic hallmark of many neurodegenerative disorders, such as Parkinson’s, Alzheimer’s and Huntington’s diseases. The ability to observe these aggregation processes and the corresponding structures formed in vitro or in situ is therefore a key requirement to understand the molecular mechanisms of these diseases. We report here on the implementation and application of Stimulated Emission Depletion (STED) microscopy to visualize the formation of amyloid fibrils in vitro.

Paper Details

Date Published: 9 March 2015
PDF: 10 pages
Proc. SPIE 9331, Single Molecule Spectroscopy and Superresolution Imaging VIII, 93310U (9 March 2015); doi: 10.1117/12.2079320
Show Author Affiliations
Pierre Mahou, Univ. of Cambridge (United Kingdom)
Nathan Curry, Univ. of Cambridge (United Kingdom)
Dorothea Pinotsi, Univ. of Cambridge (United Kingdom)
Gabriele Kaminski Schierle, Univ. of Cambridge (United Kingdom)
Clemens Kaminski, Univ. of Cambridge (United Kingdom)

Published in SPIE Proceedings Vol. 9331:
Single Molecule Spectroscopy and Superresolution Imaging VIII
Jörg Enderlein; Ingo Gregor; Zygmunt Karol Gryczynski; Rainer Erdmann; Felix Koberling, Editor(s)

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