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Proceedings Paper

Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model
Author(s): Myeongsu Seong; NoSoung Myoung; Sang-Youp Yim; Jae G. Kim
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Paper Abstract

Because mammography, the gold standard of breast cancer screening and monitoring treatment efficacy, has limitations, there is a necessity to have a new method for breast cancer patients. Raman spectroscopy is considered as one of the best alternative approaches due to its ability of visualizing (bio)chemical information of a matter. In this study, we hypothesized that the change of biochemical composition occurs earlier than morphological change in breast cancer during chemotherapy, and attempted to prove it by employing fiber-optic Raman spectroscopy for longitudinal Raman measurement in small animal breast cancer model. To confirm the hypothesis, we measured Raman spectra of a tumor breast and the contralateral breast during chemotherapy for 4 fisher 344 female rats longitudinally. Principal component analysis and Raman spectral differences between breast tumor and contralateral normal breast did not show a clear difference between them which may have been caused by interference from skin. Thus, spatially-offset Raman spectroscopy will be employed in order to acquire the Raman signal directly from tumor while suppressing Raman signal from skin for the future study.

Paper Details

Date Published: 26 February 2015
PDF: 5 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032U (26 February 2015); doi: 10.1117/12.2079279
Show Author Affiliations
Myeongsu Seong, Gwangju Institute of Science and Technology (Korea, Republic of)
NoSoung Myoung, Advanced Photonics Research Institute (Korea, Republic of)
Sang-Youp Yim, Advanced Photonics Research Institute (Korea, Republic of)
Jae G. Kim, Gwangju Institute of Science and Technology (Korea, Republic of)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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