
Proceedings Paper
Real-time Raman sensing without spectrometerFormat | Member Price | Non-Member Price |
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Paper Abstract
Raman spectroscopy has been a powerful tool in various fields of science and technology ranging from analytical
chemistry to biomedical imaging. In spite of unique features, Raman spectroscopy has also some limitations. Among
them are weak Raman signal compared to strong fluorescence and relatively complicated setup with expensive and bulky
spectrometer. In order to increase the sensitivity of Raman technique, many clever attempts have been made and some of
them were very successful including CARS, SRS, and so on. However, these still requires expensive and more
complicated setup. In this work, we have attempted to build a real-time compact Raman sensor without spectrometer.
Conventional spectrometer was replaced with a narrow-band optical filter and alternatively modulated two lasers with
slightly different wavelengths. At one laser, Raman signal from a target molecule was transmitted through the optical
filter. At the other laser, this signal was blocked by the optical filter and could not be detected by photon detector. The
alternative modulation of two lasers will modulate the Raman signal from a target molecule at the same modulation
frequency. This modulated weak Raman signal was amplified by a lock-in amplifier. The advantages of this setup
include compactness, low cost, real-time monitoring, and so on. We have tested the sensitivity of this setup and we found
that it doesn’t have enough sensitivity to detect single molecule-level, but it is still good enough to monitor the change of
major chemical composition in the sample.
Paper Details
Date Published: 11 March 2015
PDF: 4 pages
Proc. SPIE 9318, Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 93180Z (11 March 2015); doi: 10.1117/12.2079278
Published in SPIE Proceedings Vol. 9318:
Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos, Editor(s)
PDF: 4 pages
Proc. SPIE 9318, Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 93180Z (11 March 2015); doi: 10.1117/12.2079278
Show Author Affiliations
Min Ju Kim, Ulsan National Institute of Science and Technology (Korea, Republic of)
Sungho Kim, Ulsan National Institute of Science and Technology (Korea, Republic of)
Institute for Basic Science (Korea, Republic of)
Timothy K. Yang, Ulsan National Institute of Science and Technology (Korea, Republic of)
Ctr. for Soft and Living Matter, Institute of Basic Science (Korea, Republic of)
Sungho Kim, Ulsan National Institute of Science and Technology (Korea, Republic of)
Institute for Basic Science (Korea, Republic of)
Timothy K. Yang, Ulsan National Institute of Science and Technology (Korea, Republic of)
Ctr. for Soft and Living Matter, Institute of Basic Science (Korea, Republic of)
Dinesh Kumar, Ulsan National Institute of Science and Technology (Korea, Republic of)
Sung Chul Bae, Ulsan National Institute of Science and Technology (Korea, Republic of)
Institute for Basic Science (Korea, Republic of)
Sung Chul Bae, Ulsan National Institute of Science and Technology (Korea, Republic of)
Institute for Basic Science (Korea, Republic of)
Published in SPIE Proceedings Vol. 9318:
Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos, Editor(s)
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