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Proceedings Paper

Towards next generation time-domain diffuse optics devices
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Paper Abstract

Diffuse Optics is growing in terms of applications ranging from e.g. oximetry, to mammography, molecular imaging, quality assessment of food and pharmaceuticals, wood optics, physics of random media. Time-domain (TD) approaches, although appealing in terms of quantitation and depth sensibility, are presently limited to large fiber-based systems, with limited number of source-detector pairs. We present a miniaturized TD source-detector probe embedding integrated laser sources and single-photon detectors. Some electronics are still external (e.g. power supply, pulse generators, timing electronics), yet full integration on-board using already proven technologies is feasible. The novel devices were successfully validated on heterogeneous phantoms showing performances comparable to large state-of-the-art TD rack-based systems. With an investigation based on simulations we provide numerical evidence that the possibility to stack many TD compact source-detector pairs in a dense, null source-detector distance arrangement could yield on the brain cortex about 1 decade higher contrast as compared to a continuous wave (CW) approach. Further, a 3-fold increase in the maximum depth (down to 6 cm) is estimated, opening accessibility to new organs such as the lung or the heart. Finally, these new technologies show the way towards compact and wearable TD probes with orders of magnitude reduction in size and cost, for a widespread use of TD devices in real life.

Paper Details

Date Published: 5 March 2015
PDF: 7 pages
Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93191J (5 March 2015); doi: 10.1117/12.2078955
Show Author Affiliations
Alberto Dalla Mora, Politecnico di Milano (Italy)
Davide Contini, Politecnico di Milano (Italy)
Simon R. Arridge, Univ. College London (United Kingdom)
Fabrizio Martelli, Univ. degli Studi di Firenze (Italy)
Alberto Tosi, Politecnico di Milano (Italy)
Gianluca Boso, Politecnico di Milano (Italy)
Andrea Farina, Istituto di Fotonica e Nanotecnologie (IFN-CNR) (Italy)
Turgut Durduran, ICFO - Institut de Ciències Fotòniques (Spain)
Edoardo Martinenghi, Politecnico di Milano (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie (IFN-CNR) (Italy)

Published in SPIE Proceedings Vol. 9319:
Optical Tomography and Spectroscopy of Tissue XI
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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