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Proceedings Paper

Monitoring wound healing by multiphoton tomography/endoscopy
Author(s): Karsten König; Martin Weinigel; Rainer Bückle; Martin Kaatz; Christina Hipler; Katharina Zens; Stefan W. Schneider; Volker Huck
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Paper Abstract

Certified clinical multiphoton tomographs are employed to perform rapid label-free high-resolution in vivo histology. Novel tomographs include a flexible 360° scan head attached to a mechano-optical arm for autofluorescence and SHG imaging as well as rigid two-photon GRIN microendoscope. Mitochondrial fluorescent NAD(P)H, fluorescent elastin, keratin, and melanin as well as SHG-active collagen can be imaged with submicron resolution in human skin. The system was employed to study the healing of chronic wounds (venous leg ulcer) and acute wounds (curettage of actinic or seborrheic keratosis) on a subcellular level. Furthermore, a flexible sterile foil as interface between wound and focusing optic was tested.

Paper Details

Date Published: 26 February 2015
PDF: 6 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93030F (26 February 2015); doi: 10.1117/12.2078882
Show Author Affiliations
Karsten König, JenLab GmbH (Germany)
Univ. des Saarlandes (Germany)
Martin Weinigel, JenLab GmbH (Germany)
Rainer Bückle, JenLab GmbH (Germany)
Martin Kaatz, SHR Wald-Klinikum Gera gGmbH (Germany)
Univ. Hospital Jena (Germany)
Christina Hipler, Univ. Hospital Jena (Germany)
Katharina Zens, Ruprecht-Karls-Univ. Heidelberg (Germany)
Stefan W. Schneider, Ruprecht-Karls-Univ. Heidelberg (Germany)
Volker Huck, Ruprecht-Karls-Univ. Heidelberg (Germany)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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